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. 2019 Aug 14;42(5):1843–1855. doi: 10.3892/or.2019.7278

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Effects of curcumin on the cell cycle progression of NSCLC cell lines. Flow cytometric analysis and quantification of the cell cycle progression in (A and C) A549 and (B and D) H226 cells treated with curcumin at different concentrations. **P<0.01 and ***P<0.001 vs. the DMSO group. (E) Western blotting revealed that treatment of A549 cells with curcumin affected the expression of numerous cell cycle-related proteins, including cyclins, CDKs and CDK inhibitors. α-tubulin was used as a loading control. (F) Western blotting revealed that treatment of A549 cells with curcumin affected the expression and phosphorylation of Jun family members, including c-Jun, JunB and c-fos. α-Tubulin was used as a loading control. CDK, cyclin-dependent kinase.