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. 2019 Aug 20;42(5):1957–1971. doi: 10.3892/or.2019.7283

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Copyright: © Guo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Abnormal expression of miR-378a-3p and TSPAN17 are associated with GBM. (A) Relative expression of miR-378a-3p in normal adjacent tissues and tumors from GBM patients were detected by RT-qPCR (n=53). (B) Relative expression of miR-378a-3p in normal human HF, U87MG and MT-330 cells. (C) Relative expression of TSPAN17 in control and tumor samples from GBM patients were detected by RT-qPCR (n=53). (D) Relative expression of TSPAN17 in normal human HF, U87MG and MT-330 cells. (E) Correlation between miR-378a-3p and TSPAN17 expression levels in tumor of GBM patients (n=53). (F) GBM patients with high expression of miR-378a-3p exhibited improved survival rate than those with low expression (log-rank test: χ²=13.53, P=0.00048). (G) Patients with low TSPAN17 expression levels were associated with higher survival rates than those with high TSPAN17 expression (log-rank test: χ²=17.93, P=0.00032) (n=53). Data are presented as the mean ± standard deviation. Five independent experiments were performed in triplicate (n=5). Control, normal adjacent tissues; GBM, glioblastoma multiforme; miR, microRNA; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; TSPAN17, tetraspanin 17.