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. 2019 Aug 23;42(5):1781–1792. doi: 10.3892/or.2019.7293

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Copyright: © Zhuang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Effects of MSCs^Hypoxia on radiation-induced fibroblast proliferation and FMT. The following conditions were assessed: Fibroblasts alone, fibroblasts treated with radiation, and fibroblasts co-cultured with MSCs^Hypoxia or MSCsNormoxia in the presence of radiation. (A) Proliferation growth curves as determined by an MTT assay. (B and C) Col1 and α-SMA mRNA levels analyzed by RT-qPCR. (D) Expression of α-SMA was assessed by immunofluorescence staining. Each column represents the mean ± SD of three independent experiments; *P<0.05 vs. the Control; ▲P<0.05 vs. Radiation + MSCs^Hypoxia. MSCs, mesenchymal stem cells; FMT, fibroblast-to-myofibroblast transition; Col1, type I collagen; α-SMA, α-smooth muscle actin.