Figure 2.

Inhibition of MYD88 oligomerization is associated with decreased survival and increased apoptosis in MYD88-dependent DLBCL cells. (A-C) Cell viability assay using DLBCL cells treated with ST2825 or DMSO. (D) Apoptosis in DLBCL cells treated with ST2825 or DMSO for 48 h was detected by flow cytometry following annexin V/propidium iodide staining. Statistical analysis was conducted using one-way ANOVA with Dunnett's post hoc test. (E) Morphological alterations of the apoptotic cells were detected via DAPI staining. Data are presented as the mean ± standard deviation from experiments with three replicates. *P<0.05; **P<0.01; ***P<0.001. MYD88, myeloid differentiation primary response gene 88; DLBCA, diffuse large B-cell lymphoma.