Table 1.
Subject Characteristics at Time of Study Enrollment
| Feature | Overall (N = 35) | Alive/ExtubatedDay28 (n = 20) | Dead/IntubatedDay28 (n = 15) |
|---|---|---|---|
| Demographics | |||
| Age, yr, mean ± SD | 45 ± 17 | 42 ± 15 | 50 ± 19 |
| Sex, M/F | 22/13 | 13/7 | 9/6 |
| ARDS risk factors*, n (%) | |||
| Trauma | 19 (54) | 10 (50) | 9 (60) |
| Sepsis | 17 (49) | 9 (45) | 8 (53) |
| Pneumonia | 9 (26) | 5 (25) | 4 (27) |
| Other | 4 (11) | 3 (9) | 1 (7) |
| Physiologic factors, median (IQR) | |||
| Total BALF protein, g/ml | 233 (63–376) | 262 (78–477) | 195 (63–304) |
| PaO2/FiO2 ratio | 186 (158–255) | 211 (170–269) | 178 (144–225) |
| APACHE II score | 20 (17–26) | 19 (14–26) | 24 (18–28) |
| SOFA score | 8 (6–10) | 6 (4–8) | 10 (5–12) |
| Alveolar leukocyte differential, median (IQR) | |||
| % neutrophils | 35 (7–79) | 33 (7–88) | 47 (7–73) |
| % AMs | 56 (21–88) | 57 (12–86) | 53 (27–89) |
| BALF cytokine values, pg/ml, median (IQR) | |||
| IL-8 | 484 (159–1,230) | 323 (61–911) | 949 (168–1,531) |
| IL-6 | 74 (7–263) | 77 (8–318) | 45 (5–195) |
| Outcome | |||
| VFD, median (IQR) | 7 (0–23) | 21.5 (19–24) | 0 (0–0) |
| Mortality, 28 d, n (%) | 5 (14%) | 0 (0%) | 5 (33%) |
Definition of abbreviations: AM = alveolar macrophage; APACHE = Acute Physiology and Chronic Health Evaluation; ARDS = acute respiratory distress syndrome; BALF = BAL fluid; IQR = interquartile range; SOFA = Sequential Organ Failure Assessment (highest score in first 7 d); VFD = ventilator-free days.
*
Risk factors for ARDS are not mutually exclusive.