Table 2.
Differentially Expressed Genes in Alveolar Macrophages on Day 1 of Acute Respiratory Distress Syndrome
| Gene Symbol | Gene Name | FD | Nominal P Value |
|---|---|---|---|
| CTSZ | Cathepsin Z | 3.12 | 9.02 × 10−3 |
| IL18BP | IL-18–binding protein | 1.81 | 2.89 × 10−2 |
| MYOM2 | Myomesin 2 | 1.67 | 1.37 × 10−2 |
| CD274 | PD-L1 | 1.54 | 2.59 × 10−2 |
| CARD16 | Caspase recruitment domain family member 16 | 1.49 | 1.63 × 10−2 |
| MRPL52 | Mitochondrial ribosomal protein L52 | 1.49 | 3.51 × 10−2 |
| IFI27L2 | IFN-α–inducible protein 27–like 2 | 1.43 | 2.26 × 10−2 |
| ZDHHC19 | Zinc finger DHHC-type–containing 19 | 1.43 | 3.97 × 10−2 |
| NR1H3 | Nuclear receptor subfamily 1 group H member 3 | 1.43 | 3.26 × 10−2 |
| CCL22 | C-C motif chemokine ligand 22 | 1.42 | 2.66 × 10−2 |
| MYBPC3 | Myosin-binding protein C, cardiac | 1.41 | 4.11 × 10−2 |
| UNC45A | Unc-45 myosin chaperone A | 1.41 | 1.24 × 10−3 |
| THBD | Thrombomodulin | 1.38 | 3.73 × 10−2 |
| PPP3R1 | Protein phosphatase 3 regulatory subunit B, alpha | 1.37 | 3.07 × 10−2 |
| CLPTM1 | CLPTM1, transmembrane protein | 1.36 | 1.75 × 10−2 |
| RNF146 | Ring finger protein 146 | −1.35 | 4.77 × 10−2 |
| ANKRD57 | Sosondowah ankyrin repeat domain family member C | −1.37 | 4.03 × 10−2 |
| PPHLN1 | Periphilin 1 | −1.38 | 1.99 × 10−2 |
| CYP2R1 | Cytochrome P450 family 2 subfamily R member 1 | −1.38 | 3.27 × 10−3 |
| FAM23B | Transmembrane protein 236 | −1.38 | 4.36 × 10−2 |
| SF1 | Splicing factor 1 | −1.39 | 9.39 × 10−3 |
| PRKCE | Protein kinase C epsilon | −1.41 | 1.06 × 10−2 |
| SCGB1A1 | Secretoglobin family 1A member 1 | −1.43 | 2.13 × 10−2 |
| CUGBP2 | CUGBP Elav-like family member 2 | −1.44 | 4.84 × 10−2 |
| ADORA3 | Adenosine A3 receptor | −1.45 | 9.24 × 10−3 |
| NBPF1 | Neuroblastoma breakpoint family member 1 | −1.47 | 1.79 × 10−2 |
| ALCAM | Activated leukocyte cell adhesion molecule | −1.49 | 8.36 × 10−3 |
| KLF9 | Kruppel-like factor 9 | −1.49 | 4.40 × 10−2 |
| C6ORF48 | Chromosome 6 open reading frame 48 | −1.50 | 3.92 × 10−2 |
| TFCP2L1 | Transcription factor CP2 like 1 | −1.52 | 3.35 × 10−2 |
| DDIT4L | DNA damage inducible transcript 4 like | −1.55 | 1.76 × 10−2 |
| CSNK1G2 | Casein kinase 1 gamma 2 | −1.55 | 2.50 × 10−2 |
| PIK3IP1 | Phosphoinositide-3-kinase–interacting protein 1 | −1.67 | 3.80 × 10−2 |
| TSC22D3 | TSC22 domain family member 3 | −1.69 | 1.36 × 10−2 |
| AMD1 | Adenosylmethionine decarboxylase 1 | −1.69 | 3.01 × 10−2 |
| VSIG4 | V-set and immunoglobulin domain–containing 4 | −1.71 | 9.99 × 10−3 |
| MAFB | MAF BZIP transcription factor B | −1.92 | 2.52 × 10−2 |
| FKBP5 | FK506-binding protein 5 | −1.99 | 3.90 × 10−4 |
| FPR2 | Formyl peptide receptor 2 | −2.23 | 3.16 × 10−2 |
Definition of abbreviation: FD = fold difference.
FD in alive/extubatedDay28 (n = 18) compared with dead/intubatedDay28 (n = 12). The nominal P value is gene specific and not adjusted for genome-wide multiple hypothesis testing. Only genes with 1.3 FD and a nominal P value less than 0.05 are displayed. The model was adjusted for age, sex, and treatment group.