Table 2.

Associations between the Genetic Risk Score and Lung Function

	Quintile of Genetic Risk Score					Per SD (95% CI)	P Value*
	Q1	Q2	Q3	Q4	Q5
FEV1, ml
MESA Lung	Ref	12.3	−19.1	−50.3	−56.2	−22.1 (−40.3 to −3.9)	0.0173
SPIROMICS	Ref	−10.4	−58.4	−48.8	−173.1†	−56.0 (−86.5 to −26.0)	0.0003
FVC, ml
MESA Lung	Ref	30.3	28.3	10.8	21.8	7.1 (−14.9 to 29.2)	0.53
SPIROMICS	Ref	28.7	0.1	21.0	−70.1	−21.5 (−50.1 to 7.8)	0.15
FEV1/FVC, percent
MESA Lung	Ref	−0.52	−1.28‡	−1.83†	−2.21†	−0.80 (−1.13 to −0.46)	<0.0001
SPIROMICS	Ref	−0.73	−1.71	−1.74	−4.32†	−1.37 (−1.95 to −0.78)	<0.0001
Moderate-to-severe COPD
MESA Lung	Ref	0.90	1.57	2.23	2.14	1.44 (1.12 to 1.86)	0.0051
SPIROMICS	Ref	1.11‡	1.32	1.50	2.01†	1.28 (1.17 to 1.40)	<0.0001

Definition of abbreviations: CI = confidence interval; COPD = chronic obstructive pulmonary disease; MESA = Multi-Ethnic Study of Atherosclerosis; Q = quintile; Ref = reference; SPIROMICS = Subpopulations and Intermediate Outcome Measures in COPD Study.

One SD is equivalent to 6.6 in MESA Lung and 6.5 in SPIROMICS. The linear regression models were adjusted for age, age², sex, height, smoking status, pack-years, principal components of ancestry 1–10, and site.

^*Significance for linear model of continuous genetic risk score.

^†Significance for quintiles of genetic risk score: P < 0.001.

^‡Significance for quintiles of genetic risk score: P < 0.05.