Fig. 1.

16S rRNA sequencing-based OTU analysis. Non-metric multidimensional scaling (NMDS) of microbiomes from different participants (a). Each sample is represented by a dot and colors correspond to participants. Bray-Curtis dissimilarity between consecutive samples was plotted through time (b). Differences in Bray-Curtis dissimilarities shown in panel B were tested for significant participant-wise differences (c; Kruskal-Wallis test; p < 0.0001; error bars represent median and 95% confidence limits). Significant differences (p < 0.05) following correction for multiple comparisons (p < 0.05; Dunn’s test) between groups are summarized above plots by letters. Participants that share letters were not significantly different