Fig. 2.

Multiple lipid bilayer roles in molecular recognition of transmembrane proteins. According to the “microkinetic” model, the cell membrane can govern drug-binding processes by: (A) acting as a local reservoir for the drug and thus prolonging the drug exposure of the target; (B) modulating the orientation and conformation of the drug for favorable receptor binding; and (C) reducing the time the drug needs to reach its receptor, thus facilitating the approach. The long-lasting bronchodilatory effect of salmeterol (a β₂-adrenergic receptor partial agonist with a receptor-binding pharmacophore saligenin head, a hydrophobic phenylalkoxyalkyl tail, and an oxygen hinge), may be attributed to a combination of these effects. Adapted from Vauquelin (2016).