Fig. 5.

Parasutterella colonization induced changes in cecal metabolites. Changed metabolites associated with tryptophan metabolism (3-Methyldioxyindole, indole-3-carboxylic acid, indole-2-carboxylic acid, kynurenic acid, and nicotinic acid), tyrosine metabolism (p-Cresol, p-Cresol sulfate, and N-hydroxy-l-tyrosine or DOPA), and purine metabolism (inosine, hypoxanthine, and xanthine). Data are presented as box plots, where the boxes represent the 25th to 75th percentiles and the lines within the boxes represent the median. Circles represent values beyond 1.5 times the interquartile range. Significance was indicated as follows, ^##q-value < 0.01;^#q-value < 0.05. Eight biological replicates from the CON and PARA mice were plotted