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. Author manuscript; available in PMC: 2019 Oct 3.

Published in final edited form as: ChemMedChem. 2009 Aug;4(8):1354–1363. doi: 10.1002/cmdc.200900153

Cell-based assay of North-D4A (4c) on the replication of an HIV-1 vector containing wt HIV-1 RT in HOS cells [(A) ● = infectivity; ○ = cytotoxicity) and HOS-313 cells [(B), ▲ = infectivity; △ = cytotoxicity). Luciferase activity in the absence of compound was considered to be 100 and the luciferase activity in the presence of different concentrations of 4c was normalized to this value to give relative infectivity or cytotoxicity in the absence of the vector.

Cell-based assay of North-D4A (4c) on the replication of an HIV-1 vector containing wt HIV-1 RT in HOS cells [(A) ● = infectivity; ○ = cytotoxicity) and HOS-313 cells [(B), ▲ = infectivity; △ = cytotoxicity). Luciferase activity in the absence of compound was considered to be 100 and the luciferase activity in the presence of different concentrations of 4c was normalized to this value to give relative infectivity or cytotoxicity in the absence of the vector.