Overview of radiomics, the processing of radiologic imaging data. (Reprinted, with permission, from reference 91.) Regions of interest (ROIs) are segmented for the whole tumor, and multiple quantitative features are extracted. Combining information from multiple imaging modalities provides a multispectral view of the tumor and allows improved tumor characterization. Discovering relationships among the radiomic features and genomic, pathologic, and clinical data is a challenging but important step. MRS = MR spectroscopy.