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. 2019 Aug 14;97(10):4101–4113. doi: 10.1093/jas/skz271

Table 2.

Histopathology of feet and organ tissues from heat-stressed wethers fed concentrate diets supplemented with ractopamine HCl or zilpaterol HCl for 21 d

Pathology1 Environment P Dietary supplement P
Control Heat stress No Suppl. Ractopamine Zilpaterol
Foot
 Wall overgrowth 0% 92% <0.001 27% 36% 36% NS
 Vacuolated keratinocytes in coronary band 56% 42% NS 41% 56% 50% NS
Lung
 Lesions 4% 13% NS 12% 6% 6% NS
Liver
 Lesions 12% 8% NS 6% 19% 6% NS
Kidney
 Mineralization 80% 75% NS 82% 81% 69% NS
 Nephritis 12% 8% NS 6% 25% 0% NS
Cardiac
 Sacrocysts 68% 75% NS 64% 68% 81% NS
 Lymphocytic aggregates 48% 38% NS 41% 38% 50% NS

1Values are % of lambs in each group presenting the pathology. NS = not significant.