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Changes in (A) heaviness in the legs (B) and swelling in the evening symptom scores after topical application of escin-based gel or placebo in patients with saphenous vein varices. Copyright ©1988. Med Welt. Reproduced from Hoffmann J, Day U-H, Schneider B, Böhnert K-J. Percutaneous treatment of chronic venous insufficiency with an aescin-containing gel. A randomized placebo-controlled double-blind trial. Med Welt. 1988; 39:951–955.51
