Table 4. Differential gene expression in PostR biopsies of patients with FSGS partially correlates with local TNF expression and with clinical parameters.
Gene Symbol | Gene ID | TNF | DFPE | DFPW | UPCR | eGFR |
---|---|---|---|---|---|---|
TNF | 7124 | |||||
CCL2 | 6347 | |||||
CCL20 | 6364 | |||||
CCL3 | 6348 | |||||
CEBPD | 1052 | |||||
CXCL1 | 2919 | |||||
CXCL2 | 2920 | |||||
IL1B | 3553 | |||||
MAP3K8 | 1326 | |||||
NFKBIZ | 64332 | |||||
PIM2 | 11040 | |||||
SOD2 | 6648 | |||||
CSF3 | 1440 |
Red boxes—positive correlation, green boxes—negative correlation, grey boxes—no significant correlation.
DFPE = difference in foot process effacement measured in PreR and PostR biopsies; DFPW = difference in foot process width measured in PreR and PostR biopsies; UPCR = urinary protein-to-creatinine ratio, eGFR = estimated glomerular filtration rate. TNF—tumor necrosis factor, CCL2—C-C Motif Chemokine Ligand 2, CCL20—C-C Motif Chemokine Ligand 20, CCL3—C-C Motif Chemokine Ligand 3, CEBPD—CCAAT/Enhancer Binding Protein Delta, CXCL1—chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha), CXCL2—chemokine (C-X-C motif) ligand 2, IL1B—interleukin 1, beta, MAP3K8—Mitogen-Activated Protein Kinase Kinase Kinase 8, NFKBIZ—NFKB Inhibitor Zeta, PIM2—Pim-2 Proto-Oncogene, Serine/Threonine Kinase, SOD2—Superoxide Dismutase 2, CSF3—Colony Stimulating Factor 3.