Table 5. Differential gene expression in PostR biopsies of patients with FSGS partially correlates with clinical parameters.
| Gene Symbol | Gene ID | TNF | FP | UPCR | eGFR | ||||
|---|---|---|---|---|---|---|---|---|---|
| P | R2 | P | R2 | P | R2 | P | R2 | ||
| TNF | 7124 | 0.0136* | 0.237 | ||||||
| CCL2 | 6347 | 0.0005 | 0.4058 | 0.0373# | 0.2194 | 0.0042** | 0.3055 | ||
| 0.0076## | 0.3343 | 0.0122*** | 0.2436 | ||||||
| 0.0414**** | 0.1758 | ||||||||
| CCL20 | 6364 | 0.0179 | 0.2122 | 0.0060## | 0.3495 | ||||
| CCL3 | 6348 | 0.0035 | 0.3043 | ||||||
| CEBPD | 1052 | 0.0013 | 0.3568 | 0.0057## | 0.3537 | 0.0398** | 0.1711 | ||
| CXCL1 | 2919 | 0.0014 | 0.351 | ||||||
| CXCL2 | 2920 | <0.0001 | 0.6067 | 0.0255^ | 0.4551 | ||||
| IL1B | 3553 | 0.0288 | 0.1839 | 0.0351## | 0.2239 | 0.0306** | 0.1874 | ||
| 0.0242*** | 0.2021 | ||||||||
| MAP3K8 | 1326 | 0.0013 | 0.6317 | 0.0050## | 0.362 | ||||
| NFKBIZ | 64332 | <0.0001 | 0.6317 | 0.0330## | 0.2287 | 0.0288* | 0.1993 | ||
| 0.0253** | 0.1993 | ||||||||
| 0.0491*** | 0.158 | ||||||||
| PIM2 | 11040 | 0.0141 | 0.226 | 0.0119## | 0.3028 | ||||
| SOD2 | 6648 | 0.0018 | 0.3383 | 0.0289# | 0.2384 | ||||
| 0.0026## | 0.4038 | ||||||||
| CSF3 | 1440 | 0.0051## | 0.3607 | ||||||
| 0.0064### | 0.4468 | ||||||||
Red boxes—positive correlation, green boxes—negative correlation, grey boxes—no significant correlation. FP = foot process; UPCR = highest protein-to-creatinine ratio between two time points, eGFR = glomerular filtration rate.
*highest UPCR measured between days 3–30,
** highest UPCR measured between months 1–12,
*** highest UPCR measured between months 3–12,
****UPCR at 3 months,
^difference in eGFR between months 1–3,
#difference in foot process effacement (DFPE) between PreR and PostR biopsies measured by electron microscopy,
##difference in foot process width (DFPW) between PreR and PostR biopsies measured by electron microscopy,
###foot process width in PostR biopsy.
Red boxes—positive correlation, green boxes—negative correlation, grey boxes—no significant correlation. TNF—tumor necrosis factor, CCL2—C-C Motif Chemokine Ligand 2, CCL20—C-C Motif Chemokine Ligand 20, CCL3—C-C Motif Chemokine Ligand 3, CEBPD—CCAAT/Enhancer Binding Protein Delta, CXCL1—chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha), CXCL2—chemokine (C-X-C motif) ligand 2, IL1B—interleukin 1, beta, MAP3K8—Mitogen-Activated Protein Kinase Kinase Kinase 8, NFKBIZ—NFKB Inhibitor Zeta, PIM2—Pim-2 Proto-Oncogene, Serine/Threonine Kinase, SOD2—Superoxide Dismutase 2, CSF3—Colony Stimulating Factor 3.