Table 2. Changes in the registration rates of brain and eye anomalies and non-brain or eye anomalies/10,000 live births following the Zika event in Brazil and regions, from 2010–2017.

Group of Anomalies	Brazil	North	Northeast	Midwest	South	Southeast
	Estimate	Estimate	Estimate	Estimate	Estimate	Estimate
	95% CI	95% CI	95% CI	95% CI	95% CI	95% CI
Brain and eye anomalies
Pre-Zika starting level	8.24	7.77	7.53	6.80	9.16	8.87
	[7.92–8.57]	[6.97–8.56]	[6.83–8.23]	[6.00–7.61]	[8.49–9.83]	[8.36–9.39]
Pre-Zika event* monthly change	-0.01	-0.01	0.01	0.01	-0.01	-0.01
	[-0.01–0.01]	[-0.02–0.02]	[-0.00–0.03]	[-0.02–0.03]	[-0.03–0.01]	[-0.02–0.01]
Immediate change	14.92	6.64	37.07	6.78	0.03	8.64
	[6.66–23.18]	[3.02–10.26]	[12.88–61.26]	[3.18–10.37]	[-1.31–1.36]	[4.42–12.87]
Post-Zika event* monthly change	-0.62	-0.22	-1.75	-0.22	0.01	-0.24
	[-1.05 - -0.19]	[-0.40 - -0.03]	[-3.00 - -0.49]	[-0.38 - -0.06]	[-0.06–0.07]	[-0.46 - -0.02]
Non-brain or eye anomalies
Pre-Zika starting level	69.57	48.22	60.58	62.21	79.13	80.44
	[67.66–71.49]	[45.68–50.76]	[57.66–63.51]	[59.16–65.26]	[76.54–81.73]	[77.09–83.79]
Pre-Zika event* monthly change	-0.03	-0.12	-0.03	-0.16	-0.10	0.02
	[-0.08–0.01]	[-0.19 - -0.05]	[-0.09–0.03]	[-0.24 - -0.08]	[-0.17 - -0.03]	[-0.07–0.11]
Immediate change	5.20	4.20	10.35	5.42	-1.60	4.34
	[2.30–8.10]	[0.50–7.90]	[6.07–14.62]	[-0.17–11.01]	[-5.69–2.49]	[-1.09–9.77]
Post-Zika event* monthly change	0.22	0.32	0.03	0.10	0.18	0.38
	[0.08–0.36]	[0.14–0.50]	[-0.20–0.25]	[-0.23–0.42]	[-0.05–0.41]	[0.06–0.69]