Figure 3.

Peptide and reagent scope of the Pd-mediated allylation of oligopeptides. Peptide sequences containing internal, terminal, and multiple Cys residues were subjected to site-selective allylation, enabling the introduction of native prenyl groups and bioconjugation handles (azide/alkyne groups) as well as a fluorescent NBD tag and a biotin affinity tag. All modified peptides were purified, isolated, and characterized by LC-MS analysis.