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. Author manuscript; available in PMC: 2019 Oct 3.
Published in final edited form as: J Pediatr. 2019 Jun 5;211:63–71.e6. doi: 10.1016/j.jpeds.2019.04.046

Table 2.

PH subtypes by race and ethnicity

PH subtypes Race Ethnicity
American Indian / Alaska Native (n=14) Asian (n=129) Black (n=187) Native Hawaiian / other Pacific Islander (n=10) White (n=852) Multi-racial (n=23) Not specified (n=203) Hispanic (n=227) Non-Hispanic (n=1056) Unknown (n=134)
PAH 8 (57.1) 75 (58.1) 58 (31.2) 6 (60.0) 361 (42.4) 6 (26.1) 77 (37.9) 101 (44.5) 440 (41.7) 50 (37.3)
 Idiopathic 1 (7.1) 20 (15.5) 10 (5.4) 2 (20.0) 109 (12.8) 4 (17.4) 17 (8.4) 26 (11.5) 125 (11.8) 12 (9.0)
 Heritable 0 5 (3.9) 2 (1.1) 0 14 (1.6) 1 (4.3) 4 (2.0) 4 (1.8) 19 (1.8) 3 (2.2)
 Drugs/toxins 0 0 0 0 0 0 2 (1.0) 1 (0.4) 0 1 (0.7)
 Associated PAH 7 (50.0) 50 (38.8) 46 (24.7) 4 (40.0) 241 (28.3) 1 (4.3) 54 (26.6) 70 (30.8) 299 (28.3) 34 (25.4)
 CTD 0 0 2 (1.1) 0 2 (0.2) 0 3 (1.5) 0 3 (0.3) 4 (3.0)
 HIV 0 0 0 0 0 0 0 0 0 0
 Portal hypertension 0 1 (0.8) 1 (0.5) 0 3 (0.4) 0 1 (0.5) 2 (0.9) 4 (0.4) 0
 CHD 7 (50.0) 49 (38.0) 41 (22.0) 4 (40.0) 238 (27.9) 1 (4.3) 50 (24.6) 68 (30.0) 292 (27.7) 30 (22.4)
 Schistosomiasis 1 (7.1) 0 0 1 (10.0) 2 (0.2) 0 0 1 (0.4) 3 (0.3) 0
PVOD 0 0 3 (1.6) 1 (10.0) 2 (0.2) 1 (4.3) 2 (1.0) 4 (1.8) 5 (0.5) 0
PPHN 0 5 (3.9) 9 (4.8) 0 22 (2.6) 1 (4.3) 9 (4.4) 7 (3.1) 32 (3.0) 7 (5.2)
Left-heart disease 0 3 (2.3) 4 (2.2) 1 (10.0) 32 (3.8) 1 (4.3) 8 (3.9) 7 (3.1) 34 (3.2) 8 (6.0)
Lung disease 6 (42.9) 43 (33.3) 100 (53.8) 2 (20.0) 417 (48.9) 14 (60.9) 106 (52.2) 105 (46.3) 516 (48.9) 67 (50.0)
CTEPH 0 0 3 (1.6) 0 3 (0.4) 0 1 (0.5) 1 (0.4) 6 (0.6) 0
Unclear mechanisms 0 3 (2.3) 10 (5.4) 0 17 (2.0) 0 1 (0.5) 5 (2.2) 24 (2.3) 2 (1.5)
 Hematological 0 2 (1.6) 3 (1.6) 0 3 (0.4) 0 0 0 7 (0.7) 1 (0.7)
 Systemic disorders 0 0 2 (1.1) 0 5 (0.6) 0 0 2 (0.9) 5 (0.5) 0
 Metabolic disorders 0 0 1 (0.5) 0 1 (0.1) 0 1 (0.5) 2 (0.9) 1 (0.1) 0
 Segmental PH 0 1 (0.8) 0 0 2 (0.2) 0 0 0 2 (0.2) 1 (0.7)
 Others 0 0 1 (0.5) 0 2 (0.2) 0 0 1 (0.4) 2 (0.2) 0