Fig. 2. Neuropathological and molecular traits mediating the AD-PRS to motor impairment.
a Associations of neuropathologies and molecular signatures with global parkinsonism score and dexterity. The sign of negative log 10 of p value indicates the direction of effect. b GO enrichment map for histone coacetylation modules. GO enrichment for histone coacetylation modules were conducted using the GREAT algorithm and the significant associations (FDR < 0.05) were visualized by EnrichmentMap