Fig. 3. Genomic context of ASM variants, and methylation and eQTL information for cg13047596.

Genes are depicted in dark blue, showing the direction of transcription with an arrow; CpG sites inspected in the reference studies appear in brown; framed CpG sites indicate those sites showing differential levels of methylation for the associated ASM SNPs, and brown arrows indicate the effect on methylation of the ADHD risk variants, with indication of the brain regions where the ASMs were described. The tagSNPs are underscored. The colored rhombuses show the LD blocks present in each region. The colored dots for eQTLs indicate the effect on gene expression of the ADHD risk allele, according to the legend (red: over-expression, blue: under-expression). The number of enhancer (H3K4me1 and H3K27ac) and promoter (H3K4me3 and H3K9ac) histone marks found in the different brain areas are displayed for each SNP. ‘-' indicates no known enhancer or promoter histone marks