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. 2019 Oct 3;9:14290. doi: 10.1038/s41598-019-50807-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Orally delivered SSRI and acutely delivered SSRI to the intestinal lumen increase vagal firing. (A) Time interval between vagal spike firing following oral SSRI and NDRI feeding. (B) Time interval between vagal spike firing following acute presentation of sertraline to intestinal lumen. (C) Time interval between vagal spike firing following acute presentation of fluoxetine to intestinal lumen. (D) Time interval between vagal spike firing following acute presentation of bupropion to intestinal lumen. Statistics for acute experiments are paired, two-tailed t test and fed experiment one way ANOVA with Dunnett’s multiple comparison post hoc. Bars are means ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, (fed experiments, n = 5–8 animals/30–70 recordings/group, acute experiments, n = 5–10 animals/55–60 recordings/group).