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. 2019 Oct 3;5:35. doi: 10.1038/s41540-019-0112-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Statin resistance of SGRP strains and backcross methodology to construct ssDMA libraries that represent genome-wide deletion libraries of these SGRP strains. a, b Serial dilutions of three SGRP strains (Y55, UWOPS87-2421 and YPS606) resistant to a atorvastatin and b cerivastatin relative to BY4742 in the S288C background. c Outline of marker switch method used to introduce the URA3 marker into the SGRP strains. d Outline of the method used to cross and backcross the SGRP strains with the S288C deletion library (DMA) to produce the ssDMA libraries