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. 2019 Oct 3;9:244. doi: 10.1038/s41398-019-0580-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Juvenile mutant mice caused injury to littermates as illustrated by a positive correlation between the percentage of injured mice and the percentage of homozygous mutants within the litter counted at day 26 of age. n = 17 litters, 8–10 mice per litter (Pearson correlation, P < 0.0001). b Transient growth retardation of homozygotes around weaning (two-way repeated measure ANOVA, genotype: F_(2,374) = 84.43, P = 0.00014; Bonferroni post hoc test, *P < 0.05, ***P < 0.001). c Wire hanging time of day 16 mice (one-way ANOVA P = 0.0126; Tukey’s post hoc test, *P < 0.05). Data collected from six litters. d–i Behavioral tests at young adulthood: d Mutants showed anxiety behavior in the open field test (center entries: one-way ANOVA, P < 0.0001; center duration: one-way ANOVA, P < 0.0001. Tukey’s post hoc test, ***P < 0.001, ****P < 0.0001). e Anxiety behavior in the elevated-plus maze as indicated by increased time spent in close arms and reduced entries to open arms (two-way ANOVA, time spent in arms: genotype: F_(1,38) = 46.69, P < 0.0001; arm entries, genotype: F_(1,38) = 13.06, P = 0.0009; Bonferroni post hoc test, ***P < 0.001). f Heterozygous and homozygous mice showed a trend of increased social interaction with the stranger mouse (Sniffing: one-way ANOVA, P = 0.0399, Tukey’s post hoc test, *P < 0.05; following: one-way ANOVA, P = 0.0623). g Increased sociability of heterozygous and homozygous mutants in the three-chamber test (two-way ANOVA: Sociability, genotype: F_(2,40) = 34.90, P < 0.0001; Social Novelty, genotype: F_(2,40) = 13.75, P < 0.0001; Bonferroni post hoc test, *P < 0.05, **P < 0.01, ***P < 0.001). h Mutant mice showed a significantly reduced preference for sucrose solution on the first day of test (two-way repeated measure ANOVA, genotype: F_(1,185) = 6.99, *P = 0.011; Bonferroni post hoc test, **P < 0.01). i Impaired spatial working memory as suggested by reduced alternation in arm entry in Y-maze (one-way ANOVA, P = 0.003; Tukey’s post hoc test, *P < 0.05, ***P < 0.001). Number of mice indicated in graph or under n in diagram. +/+ wild-type; +/m heterozygotes; m/m: homozygous Lrrc7 mutant