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. 2019 Oct 3;10:4496. doi: 10.1038/s41467-019-12505-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Solitary chemosensory cells in gingival epithelium. a Expression in gingiva of mRNAs for taste transduction elements examined by RT-PCR. TB taste buds, RT +/− with/without reverse transcription. Uncropped scans of the gel are provided in the Source Data file. b Expression in gingiva of gustducin (Gnat3) and phospholipase Cβ2 (Plcβ2) in wild-type (WT), Gnat3^−/−, and Pou2f3^−/− mice. Nuclei stained by DAPI are blue. White dotted lines show tooth margins. T tooth facing side, V vestibular groove facing side. Yellow dotted lines indicate the fields with magnified views. Scale bars: 150 μm. c Responses of HEK293 cells transfected with Tas2r105 and chimeric reporter G protein (Gα16Gust44) to topically administered stimuli. The pseudocolor map represents calcium changes (R/R₀) measured by fluorescence intensity. LasI bacterially produced 3-oxo-C12-homoserine lactone (HSL), EsaI bacterially produced 3-oxo-C6-HSL, MeOH methanol vehicle control, ISO isoproterenol positive control. d Dose-dependent calcium responses to LasI of HEK293 cells transfected with Tas2r105 and Gα16Gust44. Source data are provided as a Source Data file