Fig. 5. Phlpp1-deleption prevented the continuous loss of IVD height 8 months after injury.

a) representative X-ray images of tail spines 2 and 8 months after injury. Yellow arrows indicateinjured IVD levels. b) DHI quantification in IVD sections. DHI was decreased both in WT (n = 18) and Phlpp1 KO (n = 12) mice 2 months after injury. By 8 months, the DHI was maintained in Phlpp1 KO mice (n = 10) after injury, but not in WT mice (n = 5). Two-way ANOVAs were used to assess the effect of injury and genotype