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. 2019 Sep 27;10:1041. doi: 10.3389/fneur.2019.01041

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Copyright © 2019 Peng, Ling, Song, Gao, Liang, Fang and Cang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dexmedetomidine upregulated GLT-1 expression and the levels of phospho-Akt/Akt in primary astrocytes. (A) Dexmedetomidine significantly upregulated GLT-1 at 100 nM for 30 min (p < 0.001). (B) Phospho-Akt was obviously increased after of dexmedetomidine treatment and the ratio of p-Akt/Akt in Dex group was increased (p < 0.001). Box plots show the median, interquartile, and range, considering control group mean values as 100% (n sample = 12 cell wells per group, 3 independent cell preparations were performed). ***p < 0.001 vs. Control group.