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Mechanism of neuroprotection mediated by dexmedetomidine in astrocytes and MCAO rats. Dexmedetomidine (Dex) improved glutamate transporter-1 (GLT-1) expression by activating α2 adrenergic receptor through PI3K/Akt signaling pathway. Upregulation of GLT-1 enhanced the uptaken of extracellular glutamate (Glu) to protect neurons from excitotoxicity. The effect of dexmedetomidine improved the neurological deficit and reduced the infarct volume in MCAO model rats.
