Fig. 8.

Function of a human-derived organoids transplanted in the epididymal fat pad. a Human C-peptide measurements of mice transplanted with 300 islet organoids (IC-hAEC group, blue squares, n = 10), or with 300 islet-cell spheroids (IC group; magneta circles, n = 8) ***p < 0.0007, unpaired Student’s t test. b Human C-peptide levels after intraperitoneal glucose challenge 4 weeks after transplantation. Magneta circles: IC, blue squares: IC-hAEC. **p < 0.008, unpaired Student’s t test, n = 5. c Representative images of the graft stained for insulin (red) and glucagon (green). Scale bar, upper panel 500 μm, lower panel 50 μm