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. 2019 Oct 3;10:4486. doi: 10.1038/s41467-019-12211-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Haplotype-resolved Hi-C to characterize embryonic homolog pairing. a Generation of Hi-C libraries using 2–4 h hybrid embryos and b haplotype-resolved mapping. c Homolog pairing as assessed by FISH. Nuclei are considered paired nuclei when FISH signals are ≤0.8 μm (center-to-center distance) apart. Bar = 1 μm. d Location of FISH targets (heterochromatin, dark gray; euchromatin, light gray; centromere, black circle). e Percentage of nuclei showing paired loci in 2–4 h embryos (error bars, standard deviation of at least three replicates; n ≥ 100 nuclei/replicate; *P < 0.0001, Fisher’s two-tailed exact). Source data are provided as a Source Data file