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. 2019 Oct 3;9:14281. doi: 10.1038/s41598-019-50656-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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STING-deficient mice demonstrate attenuation of DSS-induced acute colitis. Representative histological sections harvested from (a) WT, (b) DSS-treated WT and (c) DSS-treated Tmem173^gt mice. After 7 days of DSS treatment, crypt loss, as well as infiltration and hypertrophy, was reduced in the DSS-treated Tmem173^gt mice when compared to WT mice. In addition, epithelial brush border (black arrowheads) and goblet cell (yellow arrowheads) losses were reduced in the colonic tissues of DSS-treated Tmem173^gt mice when compared to similarly treated WT controls. (d) Although the HAI was elevated in all DSS-treated mice when compared to non-treated WT mice, colonic damage in the DSS-treated Tmem173^gt mice was markedly reduced. PAS stain. Sections imaged using a 20x objective. Statistical significance was assessed by one-way ANOVA followed by Tukey’s multiple comparisons post-hoc test between all groups. Values represent means ± SEM, n ≥ 8 mice per group, ***P < 0.001 relative to DSS-treated WT.