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. Author manuscript; available in PMC: 2020 Feb 12.
Published in final edited form as: Nat Biotechnol. 2019 Aug 12;37(10):1155–1162. doi: 10.1038/s41587-019-0217-9

Figure 2. Mappability of the human genome with CCS reads.

Figure 2.

(a) Percentage of the non-gap GRCh37 human genome covered by at least 10 reads from 28-fold coverage NGS (2×250 bp, HiSeq 2500) and CCS (13.5 kb) datasets at different mapping quality thresholds. (b) Coverage of the congenital deafness gene STRC in HG002 with 2×250 bp NGS reads and 13.5 kb CCS reads at a mapping quality threshold of 10. (c) Improvement in mappability with 13.5 kb CCS reads for 193 human genes previously reported as medically-relevant and problematic to map with NGS reads28.