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. Author manuscript; available in PMC: 2020 Mar 18.
Published in final edited form as: Nature. 2019 Sep 18;574(7776):57–62. doi: 10.1038/s41586-019-1570-z

Figure 2 |. Immune cell chemotaxis towards Y. pestis is mediated by the T3SS and FPR1.

Figure 2 |

Numbers of migrating immune cells were quantified in a transwell assay primed with mock, Y. pestis KIM D27 (WT) or KLD29 (ΔlcrV) (107 CFU/ml). Chemotaxis toward fMLF is shown as a control: U937, FPR1−/− and FPR1−/− (pFPR1) cells (a); human neutrophils (b); granulocytes from wild-type (C57BL/6) and mFpr1−/− mice (c). One of three repeats is shown and error bars represent the s.e.m. (n = 3 biological replicates). One-way ANOVA with Bonferroni Correction (a, b) and un-paired Student’s t-test (c) were used to identify significant differences: ***, P<0.001; **, P <0.01; *, P <0.05; ns, not significant.