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Boxplot comparison of Opioid, Benzodiazepine (BZD) and Dexmedetomidine (DEX) total drug dosages (OR and ICU combined) between Pre and Post Clinical Practice Guideline cohorts. Opioid dosage represented as Fentanyl Equivalents (FE) and Benzodiazepine dosage as Midazolam Equivalents (ME).