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. Author manuscript; available in PMC: 2020 Oct 4.
Published in final edited form as: Stat Methods Med Res. 2019 Apr 4;29(2):498–507. doi: 10.1177/0962280219840050

Table 1.

Trial properties under different uniform prior distributions for σ using our Joint Bayesian hierarchical model.

Scenario Stratum Hypothesis Design Type I Power En PET
I A 0.1 vs. 0.3 U (0,0.1) 0.05 0.75 11 0.88
U (0,1) 0.04 0.83 12 0.85
U (0,10) 0.05 0.78 13 0.75
U (0,100) 0.04 0.77 13 0.75
B 0.5 vs. 0.75 U (0,0.1) 0.07 0.85 12 0.79
U (0,1) 0.08 0.90 13 0.73
U (0,10) 0.10 0.86 14 0.62
U (0,100) 0.10 0.86 14 0.60
II A 0.1 vs. 0.3 U (0,0.1) 0.04 0.69 11 0.88
U (0,1) 0.04 0.79 11 0.86
U (0,10) 0.05 0.77 13 0.75
U (0,100) 0.04 0.77 13 0.75
B 0.5 vs. 0.7 U (0,0.1) 0.09 0.82 13 0.66
U (0,1) 0.10 0.82 14 0.58
U (0,10) 0.11 0.74 15 0.50
U (0,100) 0.12 0.74 15 0.49
III A 0.1 vs. 0.25 U (0,0.1) 0.07 0.70 12 0.78
U (0,1) 0.05 0.73 13 0.73
U (0,10) 0.05 0.66 13 0.70
U (0,100) 0.05 0.63 13 0.72
B 0.5 vs. 0.7 U (0,0.1) 0.09 0.77 13 0.66
U (0,1) 0.10 0.80 14 0.58
U (0,10) 0.11 0.73 15 0.50
U (0,100) 0.11 0.73 15 0.49
IV A 0.1 vs. 0.25 U (0,0.1) 0.07 0.78 12 0.80
U (0,1) 0.05 0.78 13 0.73
U (0,10) 0.05 0.69 13 0.71
U (0,100) 0.05 0.65 13 0.72
B 0.5 vs. 0.75 U (0,0.1) 0.07 0.78 12 0.80
U (0,1) 0.07 0.87 13 0.73
U (0,10) 0.10 0.86 14 0.63
U (0,100) 0.10 0.85 14 0.60

En: expected sample size; PET: probability of early stopping.