Table 1.
Trial properties under different uniform prior distributions for σ using our Joint Bayesian hierarchical model.
| Scenario | Stratum | Hypothesis | Design | Type I | Power | En | PET |
|---|---|---|---|---|---|---|---|
| I | A | 0.1 vs. 0.3 | U (0,0.1) | 0.05 | 0.75 | 11 | 0.88 |
| U (0,1) | 0.04 | 0.83 | 12 | 0.85 | |||
| U (0,10) | 0.05 | 0.78 | 13 | 0.75 | |||
| U (0,100) | 0.04 | 0.77 | 13 | 0.75 | |||
| B | 0.5 vs. 0.75 | U (0,0.1) | 0.07 | 0.85 | 12 | 0.79 | |
| U (0,1) | 0.08 | 0.90 | 13 | 0.73 | |||
| U (0,10) | 0.10 | 0.86 | 14 | 0.62 | |||
| U (0,100) | 0.10 | 0.86 | 14 | 0.60 | |||
| II | A | 0.1 vs. 0.3 | U (0,0.1) | 0.04 | 0.69 | 11 | 0.88 |
| U (0,1) | 0.04 | 0.79 | 11 | 0.86 | |||
| U (0,10) | 0.05 | 0.77 | 13 | 0.75 | |||
| U (0,100) | 0.04 | 0.77 | 13 | 0.75 | |||
| B | 0.5 vs. 0.7 | U (0,0.1) | 0.09 | 0.82 | 13 | 0.66 | |
| U (0,1) | 0.10 | 0.82 | 14 | 0.58 | |||
| U (0,10) | 0.11 | 0.74 | 15 | 0.50 | |||
| U (0,100) | 0.12 | 0.74 | 15 | 0.49 | |||
| III | A | 0.1 vs. 0.25 | U (0,0.1) | 0.07 | 0.70 | 12 | 0.78 |
| U (0,1) | 0.05 | 0.73 | 13 | 0.73 | |||
| U (0,10) | 0.05 | 0.66 | 13 | 0.70 | |||
| U (0,100) | 0.05 | 0.63 | 13 | 0.72 | |||
| B | 0.5 vs. 0.7 | U (0,0.1) | 0.09 | 0.77 | 13 | 0.66 | |
| U (0,1) | 0.10 | 0.80 | 14 | 0.58 | |||
| U (0,10) | 0.11 | 0.73 | 15 | 0.50 | |||
| U (0,100) | 0.11 | 0.73 | 15 | 0.49 | |||
| IV | A | 0.1 vs. 0.25 | U (0,0.1) | 0.07 | 0.78 | 12 | 0.80 |
| U (0,1) | 0.05 | 0.78 | 13 | 0.73 | |||
| U (0,10) | 0.05 | 0.69 | 13 | 0.71 | |||
| U (0,100) | 0.05 | 0.65 | 13 | 0.72 | |||
| B | 0.5 vs. 0.75 | U (0,0.1) | 0.07 | 0.78 | 12 | 0.80 | |
| U (0,1) | 0.07 | 0.87 | 13 | 0.73 | |||
| U (0,10) | 0.10 | 0.86 | 14 | 0.63 | |||
| U (0,100) | 0.10 | 0.85 | 14 | 0.60 |
En: expected sample size; PET: probability of early stopping.