Table 4.

Trial properties using our JBHM with progression times generated from a Weibull distribution with a shape parameter (S) equal to 0.5, 1 or 2.

Scenario	Stratum	Hypothesis	S	Type I	Power	En	PET
I	A	0.1 vs. 0.3	0.5	0.04	0.82	11	0.87
			1	0.04	0.83	12	0.85
			2	0.04	0.84	12	0.83
	B	0.5 vs. 0.75	0.5	0.08	0.89	12	0.78
			1	0.08	0.90	13	0.73
			2	0.09	0.91	13	0.67
II	A	0.1 vs. 0.3	0.5	0.04	0.78	11	0.87
			1	0.04	0.79	11	0.86
			2	0.04	0.81	12	0.82
	B	0.5 vs. 0.7	0.5	0.10	0.81	13	0.65
			1	0.10	0.82	14	0.58
			2	0.11	0.83	15	0.52
III	A	0.1 vs. 0.25	0.5	0.05	0.73	12	0.75
			1	0.05	0.73	13	0.73
			2	0.05	0.74	13	0.69
	B	0.5 vs. 0.7	0.5	0.09	0.78	13	0.65
			1	0.10	0.80	14	0.58
			2	0.10	0.80	15	0.51
IV	A	0.1 vs. 0.25	0.5	0.04	0.77	12	0.76
			1	0.05	0.78	13	0.73
			2	0.05	0.79	13	0.69
	B	0.5 vs. 0.75	0.5	0.07	0.85	12	0.78
			1	0.07	0.87	13	0.73
			2	0.08	0.88	13	0.67

En: expected sample size; PET: probability of early stopping.