. Author manuscript; available in PMC: 2020 Oct 4.

Published in final edited form as: Stat Methods Med Res. 2019 Apr 4;29(2):498–507. doi: 10.1177/0962280219840050

Table 5.

Trial properties of using our JBHM with U(0, 1) and U(0, 10) prior for σ, when there is no treatment effect in stratum A and a strong treatment effect in stratum B. The percentage of times that the trial rejects the null hypothesis (Reject) and the probability of early stopping (PET) are summarized.

Scenario	Hypothesis	True success rate	U (0,1)		U (0, 10)
Scenario	Hypothesis	True success rate	Reject	PET	Reject	PET
I	0.1 vs. 0.3	0.1	0.17	0.61	0.09	0.74
	0.5 vs. 0.75	0.75	0.75	0.21	0.83	0.12
II	0.1 vs. 0.3	0.1	0.14	0.66	0.08	0.75
	0.5 vs. 0.7	0.7	0.68	0.19	0.72	0.11
III	0.1 vs. 0.25	0.1	0.16	0.48	0.09	0.59
	0.5 vs. 0.7	0.7	0.66	0.18	0.72	0.11
IV	0.1 vs. 0.25	0.1	0.21	0.41	0.10	0.55
	0.5 vs. 0.75	0.75	0.73	0.21	0.82	0.12

En: expected sample size; PET: probability of early stopping.