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. Author manuscript; available in PMC: 2020 Oct 4.
Published in final edited form as: J Mol Biol. 2019 Apr 4;431(21):4229–4246. doi: 10.1016/j.jmb.2019.03.027

Figure 1: Schematic of the A. fumigatus cell wall.

Figure 1:

The composition of the A. fumigatus cell wall depends on the fungal morphotype. In conidia, a hydrophobin and melanin layer shields the immunogenic core of the cell well, consisting of carbohydrates and glycoproteins. Germlings and hyphae lose the outer conidial layer, leading to exposure of immunoreactive polysaccharides and the eventual synthesis of an outer galactosaminogalactan layer. The indicated receptors trigger innate immune activation in response to exposure of defined polysaccharide and melanin ligands.