Figure 3.
Intranasal administration of rat rOPN ameliorated neurological deficits at 24 h after SAH. A, rOPN improved modified Garcia score and beam balance score at 24 h after SAH. Sample size is 18, n = 6 per group. Data were analyzed using Kruskal‐Wallis test, For modified Garcia results, χ 2 = 13.441. For beam balance scores, χ 2 = 12.475. B, Intranasal administration of rat rOPN increased the total amount of full‐length OPN and its cleavage products in the left hemispheres of rat brain at 24 h after SAH. Sample size is 18, n = 6 per group. Data were presented as mean ± SD. For full‐length OPN, mean ± SD is 0.97 ± 0.6647 in Sham group, 20.08 ± 10.63 in SAH + Vehicle group, 59.93 ± 30.58 in SAH + rOPN group; F = 15.52. For OPN cleavage products, mean ± SD is 0.993 ± 0.9482 in Sham group, 7.963 ± 7.649 in SAH + Vehicle group, 62.98 ± 33.36 in SAH + rOPN group; F = 17.71. * P < .05, **P < .01, ***P < .001 vs Sham group; #P < .05, ##P < .01 vs SAH + Vehicle group