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. 2019 Oct;10(5):944–956. doi: 10.21037/jgo.2019.05.10

Table 3. Treatment related toxicity.

Cumulative toxicology analysis Number of patients
Clinical toxicities
   Treatment-related mortality 0
   Non-specific abdominal pain (mild, grade 1) 2
   Fatigue
       Total 8
       Grade 1 4
       Grade 2 1
       Grade 3 3
Laboratory toxicities
   Hyperbilirubinemia
       Total 3
       Grade 1 1
       Grade 2 0
       Grade 3Ψ 2
       Grade ≥4 0
   Transaminitis (AST/ALT)
       Total 5
       Grade 1 2
       Grade 2 1
       Grade 3 2
       Grade ≥4 0
   Elevated alkaline phosphatase
       Total 3
       Grade 1* 1
       Grade 2* 2
       Grade ≥3 0
   Hematological toxicity (RBC, WBC, Platelets)
       Grade 1 2
   Renal toxicity
       Total 0

*, all cases with elevated level of alkaline phosphatase were observed with gemcitabine at 1,000 mg/m2; Ψ, grade 3 elevated level of bilirubin was seen with gemcitabine at 800 mg/m2.