Table 3. Univariate and multivariate Cox proportional hazards regression model survival analysis of SII for DFS.
| Parameters | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| Age (years) | 0.521 | ||||
| <60 | 1 (reference) | ||||
| ≥60 | 1.140 (0.764–1.699) | ||||
| Gender | 0.933 | ||||
| Male | 1 (reference) | ||||
| Female | 1.020 (0.640–1.627) | ||||
| Postoperative chemotherapy | 0.942 | ||||
| Yes | 1 (reference) | ||||
| No | 0.984 (0.631–1.534) | ||||
| Radical resection | <0.001 | <0.001 | |||
| R0 | 1 (reference) | 1 (reference) | |||
| R1 | 0.934 (0.528–1.654) | 0.960 (0.563–1.637) | |||
| R2 | 7.171 (3.970–12.955) | 6.163 (3.580–10.609) | |||
| Type of surgery | 0.003 | 0.008 | |||
| Distal gastrectomy | 1 (reference) | 1 (reference) | |||
| Proximal gastrectomy | 1.718 (0.551–5.359) | 0.874 (0.402–1.902) | |||
| Total gastrectomy | 2.951 (1.581–5.508) | 1.818 (1.231–2.685) | |||
| Differentiation | 0.698 | ||||
| Poorly differentiated | 1 (reference) | ||||
| Moderately differentiated | 1.144 (0.728–1.799) | ||||
| Well differentiated | 0.745 (0.215–2.581) | ||||
| Primary tumor site | 0.231 | ||||
| Upper 1/3 | 1 (reference) | ||||
| Middle 1/3 | 1.402 (0.588–3.344) | ||||
| Low 1/3 | 2.180 (0.795–5.981) | ||||
| Pathology | 0.022 | 0.016 | |||
| Adenocarcinoma | 1 (reference) | 1 (reference) | |||
| Mucinous carcinoma | 3.007 (1.142–7.916) | 2.052 (1.216–3.464) | |||
| Signet ring cell carcinoma | 3.863 (1.267–11.777) | 1.665 (1.002–2.767) | |||
| Mixed carcinoma | 2.086 (0.652–6.677) | 0.962 (0.490–1.888) | |||
| MLNR | 0.011 | 0.022 | |||
| <0.33 | 1 (reference) | 1 (reference) | |||
| ≥0.33 | 1.589 (1.019–2.479) | 1.825 (1.231–3.027) | |||
| White blood cell (W, ×109 cells/L) | 0.749 | ||||
| <5.80 | 1 (reference) | ||||
| ≥5.80 | 0.889 (0.433–1.827) | ||||
| Hemoglobin (Hb, ×109 cells/L) | 0.963 | ||||
| <126 | 1 (reference) | ||||
| ≥126 | 0.990 (0.658–1.490) | ||||
| Neutrophils (N, ×109 cells/L) | 0.73 | ||||
| <3.38 | 1 (reference) | ||||
| ≥3.38 | 1.123 (0.580–2.176) | ||||
| Monocyte (M, ×109 cells/L) | 0.999 | ||||
| <0.44 | 1 (reference) | ||||
| ≥0.44 | 1.000 (0.650–1.540) | ||||
| Platelet (P, ×109 cells/L) | 0.905 | ||||
| <222 | 1 (reference) | ||||
| ≥222 | 1.029 (0.647–1.637) | ||||
| Lymphocyte (L, ×109 cells/L) | 0.009 | 0.005 | |||
| <1.80 | 1 (reference) | 1 (reference) | |||
| ≥1.80 | 1.781 (1.158–2.741) | 1.662 (1.161–2.378) | |||
| SII (×109 cells/L) | 0.025 | 0.012 | |||
| <600 | 1 (reference) | 1 (reference) | |||
| ≥600 | 1.726 (1.072–2.777) | 1.592 (1.108–2.286) | |||
| CEA (ng/mL) | 0.044 | 0.005 | |||
| <2.46 | 1 (reference) | 1 (reference) | |||
| ≥2.46 | 1.528 (1.012–2.310) | 1.655 (1.162–2.358) | |||
| CA199 (U/mL) | 0.648 | ||||
| <12.33 | 1 (reference) | ||||
| ≥12.33 | 1.106 (0.717–1.706) | ||||
| Lauren classification | 0.285 | ||||
| Intestinal | 1 (reference) | ||||
| Diffuse | 0.683 (0.258–1.807) | ||||
| Mixed | 0.432 (0.146–1.277) | ||||
| Borrmann classification | 0.004 | 0.008 | |||
| Borrmann I | 1 (reference) | 1 (reference) | |||
| Borrmann II | 0.471 (0.118–1.876) | 0.347 (0.092–1.310) | |||
| Borrmann III | 1.474 (0.399–5.447) | 0.912 (0.266–3.134) | |||
| Borrmann IV | 1.231 (0.294–5.155) | 0.721 (0.188–2.773) | |||
| Tumor size (mm) | 0.324 | ||||
| <50 | 1 (reference) | ||||
| ≥50 | 0.802 (0.518–1.243) | ||||
SII, systemic immune-inflammation index; DFS, disease-free survival.