Table 3. Summary of median OS, baseline neutrophil count, performance status, number of prior regimens, number of post treatment, response, median PFS and median OS in each category.
| Category | A (n=9) | B (n=7) | C (n=14) | D (n=10) | Total (n=40) |
|---|---|---|---|---|---|
| Percentage decrease of neutrophils (%) | <25 | 25 to <50 | 50 to <75 | ≥75 | – |
| ECOG performance status (n) | |||||
| 0–1 | 8 | 6 | 12 | 9 | 35 |
| 2 | 1 | 1 | 2 | 1 | 5 |
| Baseline neutrophil count (×109/L) | 3.89±2.39 | 3.38±1.45 | 3.40±1.21 | 4.60±1.50 | 3.99±1.83 |
| Number of prior regimens (n) | |||||
| 1 | 1 | 1 | 2 | 1 | 5 |
| 2 | 4 | 3 | 4 | 4 | 15 |
| ≥3 | 4 | 3 | 8 | 5 | 20 |
| Number of post treatment (n) | |||||
| 0 | 4 | 5 | 6 | 3 | 18 |
| 1 | 3 | 0 | 4 | 4 | 11 |
| ≥2 | 2 | 2 | 4 | 3 | 11 |
| Response | |||||
| CR (n) | 0 | 0 | 0 | 0 | 0 |
| PR (n) | 0 | 1 | 0 | 0 | 1 |
| SD (n) | 1 | 2 | 9 | 6 | 18 |
| PD (n) | 8 | 4 | 5 | 4 | 21 |
| RR (%) | 0 | 14 | 0 | 0 | 2.5 |
| DCR (%) | 11 | 43 | 64 | 60 | 45 |
| Median PFS (months) (P value) | 1.7 | 2.1 (0.02) | 4.0 (<0.001) | 4.8 (0.001) | 2.8 |
| Median OS (months) (P value) | 4.1 | 10.1 (0.04) | 10.5 (0.04) | 15.6 (0.04) | 10.1 |
CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; RR, response rate; DCR, disease control rate; PFS, progression free survival; OS, overall survival.