Table 2. Multivariate analysis of metastatic small intestinal neuroendocrine tumor patients.
| Variable | HR | 95% CI | P value |
|---|---|---|---|
| Age (years) | |||
| ≤50 | |||
| >50 | 2.10 | 1.51–2.92 | <0.001 |
| Gender | |||
| Female | |||
| Male | 1.02 | 0.8–1.28 | 0.81 |
| Race | |||
| Black/others | |||
| White | 0.96 | 0.69–1.34 | 0.85 |
| Year of diagnosis | |||
| 2000–2007 | |||
| 2008–2014 | 0.79 | 0.61–1.01 | 0.06 |
| Tumor location | |||
| NOS | |||
| Duodenum | 1.39 | 0.93–2.08 | 0.09 |
| Jejunum | 0.79 | 0.50–1.26 | 0.34 |
| Ileum | 0.80 | 0.62–1.03 | 0.09 |
| Tumor size (cm) | |||
| ≤2 | |||
| >2 | 1.27 | 0.97–1.66 | 0.07 |
| Histology | |||
| Neuroendocrine | |||
| Carcinoid | 0.68 | 0.54–0.86 | 0.001 |
| Liver metastasis | |||
| No | |||
| Yes | 1.23 | 0.90–1.68 | 0.18 |
| Grade | |||
| I | |||
| II | 1.45 | 1.11–1.91 | 0.007 |
| III/IV | 3.50 | 2.54–4.83 | <0.001 |
| Surgery | |||
| No surgery | |||
| Local resection | 0.43 | 0.32–0.59 | <0.001 |
| Radical resection | 0.43 | 0.30–0.62 | <0.001 |
HR, hazard ratio; CI, confidence interval; NOS, not otherwise specified.