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. 2019 Sep 27;10:910. doi: 10.3389/fgene.2019.00910

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Copyright © 2019 Chai, Chang, Wang, Zhang, Li, Huang, Wu, Liu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TMZ therapeutic prognosis associated CpGs’ methylation profile in MGMT unmethylated GBMs. (A) Heatmap showing the methylation levels of the 3,565 GpGs associated with the overall survival of TMZ treated patients with MGMT unmethylated GBMs. The MGMT unmethylated GBMs could be clustered into 3 clusters (Cluster A–C) according to the CpGs methylation levels. (B) Kaplan–Meier overall survival (OS) curves of TMZ treated MGMT unmethylated GBM patients (stratified by Cluster A–C) and TMZ treated MGMT methylated GBM patients. (C, D) GO biological process terms (C) and KEGG pathways (D) enriched among the genes positively and negatively corresponding to the 3,565 GpGs.