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. 2019 Sep 27;10:966. doi: 10.3389/fneur.2019.00966

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Copyright © 2019 Michael, Grigoryan, Kilday, Sumbria, Vasilevko, van Ryn, Cribbs, Paganini-Hill and Fisher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemical (A–D) and Western blot analysis (E–F) of endothelial activation (A), blood-brain barrier structure and function (B,E,F), and neuroinflammation (C,D) in Tg2576 and WT mice with/without DE. Significant difference in Iba-1- (C) and GFAP-positive (D) area of DE-treated Tg2576 mice and WT littermates and in Iba-1-positive area of vehicle-treated Tg2576 mice and WT littermates. Statistical tests: Kruskal-Wallis test followed by Dunn's multiple comparison tests. Individual data points are presented with mean and SEM error bars. ^*Indicates significant difference between means, p < 0.05. ^**Indicates significant difference between means, p < 0.01.