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. 2019 Sep 2;20(10):e48913. doi: 10.15252/embr.201948913

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© 2019 The Authors. Published under the terms of the CC BY NC ND 4.0 license

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Figure EV3 — Representative cryo‐EM densities showing fitted model for DNA and each of the histones (left), arginine anchor, and hydrophobic regions of CENP‐C^CR (right).

Surface representation of nucleosome (histone core—gray, DNA—blue), showing a hydrophobic groove (green) on the nucleosome formed by H2A^L108, CENP‐A^L135, CENP‐A^L139, and H4^V60. CENP‐C^CR is shown as a purple coil with hydrophobic sidechains in stick representation.