Table 2.

Dysregulated miRNA expressions in: SLE, Psoriasis, RA, SSc, and T1D.

Disease	Origins	Levels of miRNAs	Target genes	References
SLE	PBMCs	miR-155: + miR-146a: –	PP2Ac IFNa and IFNb	(143, 144)
SLE	T cells	miR-21: + miR-31: –	PDCD4 RhoA	(127, 129)
SLE	CD4+ T cells	miR-142-3p/5p: – miR-21, 148a, 126 and 29b: +	SAP, CD84, and Il10 DNMT1	(124–126, 128)
SLE	B cells	miR-30a: + miR-1246: –	Lyn EBF1	(134, 138)
Psoriasis	T cells	mir-210	STAT3, Lyn	(145)
	Keratinocytes	mir-17–92 cluster	–	(146)
		Mir-let 7b Mir-194	Il6 Grainyhead-like 2	(147) (148)
RA	T cells	miR-223: –	IGF-1R	(149)
RA	CD4+ T cells	miR-146a: +	FAF1	(150)
RA	Synovial fibroblasts	miR-155: +	MMP-3	(151, 152)
SSc	Fibroblasts	miR-21: + miR-29a: − miR-196a: +	Smad7 Type I and III collagen Type I collagen	(153–156)
T1D	Plasma	microRNA-16-5p,−17-5p and−20a-5p: +	—	(157)
T1D	Plasma-derived exosome	miRNAs signature	—	(158)
T1D	Treg	miR-125a-5p: +	CCR2	(159)
T1D	Beta cell	microRNA-503: +	mTOR pathway	(160)
T1D	Plasma	miRNAs profile, miRNA-320a and mRNA-486	–	(161, 162)
T1D	Urine	miRNAs profile	Predict disease	(163)

+, Increased; –, Decreased.