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. 2019 Oct 3;17:102. doi: 10.1186/s12951-019-0536-5

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — In vivo evaluation of osteointegration of the quasi-three-dimensional hierarchical topography. a Histologic analysis at the bone-implant interface of clinical titanium (control) and M-NR group after implantation for 4 and 8 weeks. The arrows indicate the inflammation regions. b The corresponding quantitative analysis of the relative bone-to-implant contact. c The evaluation of push-out strength (n ≥ 5)