Fig. 7.

In vivo antibacterial efficacy of MXF and its nanoformulations in mice with pulmonary P727 isolate infection. Survival rate of bacteria-infected mice treated with saline, blank NPs (without MXF-loaded Oxi-αCD NPs), MXF, and MXF nanoformulations (each group included five mice, each mouse received two dose of free drug or MXF-loaded NPs with 5 mg/kg of MXF at interval 2 days, while mice in the blank NPs group received equal NPs with the drug-loaded NPs group) (a). H&E-stained sections of the lung tissues from normal and infected mice (b). The images and colony counts of P727 isolate of lung tissues (c, d). The red arrow indicates that P727 isolate colony was observed in the infected lung tissues. *statistical significance at p < 0.05 vs saline; ^#statistical significance at p < 0.05 vs blank NPs; ^$statistical significance at p < 0.05 vs MXF