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. 2019 Oct 3;7:2515135519874677. doi: 10.1177/2515135519874677

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© The Author(s), 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Frequencies and phenotypes of NS3-specific CD8⁺ T cells induced by SFV immunizations. Naïve mice were primed and boosted immunized intramuscularly at a 2 week intervals with 5 × 10⁶ infectious particles of SFV-NS3/4A or SFV-sHELP-NS3/4A. (a) Kinetics of the percentage of NS3-specific cells in the total CD8⁺ blood cells. (b) Mice were sacrificed on day 24 after SFV immunizations and the percentage of NS3-specific cells in the total CD8⁺ splenocytes was determined. (c) NS3-specific CD8⁺ T cell subsets induced upon SFV immunization. Surface markers for the different subsets: effector T cells (TEFF) CD44⁺CD62L^–CD127^–, effector memory T cells (TEM) CD44⁺CD62L^–CD127⁺, central memory T cells (TCM) CD44⁺CD62L⁺CD127⁺. The percentages of each T cell subset in the total NS3-specific CD44⁺CD8⁺ splenocytes are shown. Data represent mean + or ± SEM (n = 3–4).